Endocrine Abstracts

Objective: Estrogen or raloxifen prevent estrogen deficiency-induced bone loss animals and humans. There is a medical need for agent with the positive effects of estrogen on bone and the cardiovascular system, but without the negative effects tissue. So, we investigated the effects of raloxifen on bone strength and cholesterol levels in osteoporotic rats and compared them with estrogen treatment.Methods: Thirty-one ovariectomized (OVX) Sprague-Dawney ra...

Objective: HMG Coenzyme A reductase inhibitors (statins) mainly decrease low-density lipoproteins (LDL) cholesterol but also have been found to have beneficial effects in the skeleton. The aim of this study was to examine atorvastatin effects in vivo on femoral and vertebral bone strength.Methods: An ovariectomized (OVX), a glucocorticoid induced osteoporotic (GIO) and an OVX plus GIO group of rat models were used to study the effects of atorvastatin. Sp...